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Authordc.contributor.authorKohan Ivani, Karla 
Authordc.contributor.authorCarvajal, Rodrigo 
Authordc.contributor.authorGabler Neale, Fernando 
Authordc.contributor.authorVantman, David 
Authordc.contributor.authorRomero Osses, Carmen 
Authordc.contributor.authorVega Blanco, María Margarita 
Admission datedc.date.accessioned2019-01-29T15:36:32Z
Available datedc.date.available2019-01-29T15:36:32Z
Publication datedc.date.issued2010
Cita de ítemdc.identifier.citationReproduction, Volumen 140, Issue 1, 2018, Pages 123-131
Identifierdc.identifier.issn17417899
Identifierdc.identifier.issn14701626
Identifierdc.identifier.other10.1530/REP-10-0056
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/161768
Abstractdc.description.abstractFifty to seventy percent of patients with polycystic ovary syndrome (PCOS) present hyperinsulinemia. On the other hand, reports indicate that forkhead box class O 1 (FOXO1) and peroxisome proliferator-activated receptor-g (PPARG) are involved in the insulin signaling pathway, regulating the gene expression of SLC2A4 (GLUT4). The negative effect of FOXO1 over PPARG transcription disappears when FOXO1 is phosphorylated (p-FOXO1) and excluded from the nucleus, whereas PPARG can suppress gene expression of SLC2A4. Scarce knowledge is available in endometrium of women with PCOS and hyperinsulinemia (PCOSE h-Ins) about the role of these factors. We aimed to evaluate whether the endocrine and metabolic status of PCOS modify the levels of gene and protein expression of FOXO1, PPARG, and SLC2A4 in the endometria from hyperinsulinemic PCOS women compared with controls. In endometria from control (CE, n=7) or PCOSE h-Ins (n=7), we determined the subcellular location and protein levels of p-FOXO1S
Lenguagedc.language.isoen
Publisherdc.publisherBioScientifica Ltd.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceReproduction
Keywordsdc.subjectReproductive Medicine
Keywordsdc.subjectEmbryology
Keywordsdc.subjectEndocrinology
Keywordsdc.subjectObstetrics and Gynecology
Keywordsdc.subjectCell Biology
Títulodc.titleRole of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile