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Autordc.contributor.authorSanchez, S. 
Autordc.contributor.authorTampier, 
Autordc.contributor.authorMardones, 
Fecha ingresodc.date.accessioned2019-01-29T15:43:40Z
Fecha disponibledc.date.available2019-01-29T15:43:40Z
Fecha de publicacióndc.date.issued1969
Cita de ítemdc.identifier.citationEuropean Journal of Pharmacology, Volumen 7, Issue 1, 2018, Pages 106-110
Identificadordc.identifier.issn00142999
Identificadordc.identifier.other10.1016/0014-2999(69)90171-X
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/162174
Resumendc.description.abstractThe previous administration of chloroquine to normal rats resulted in a significant increase in the lethal dose of morphine and in a higher amount of conjugated morphine in the liver. No differences were found on normorphine formation in liver of treated and untreated groups. The blood levels of free morphine at death were not significantly different in pretreated and control rats. Pretreatment with chloroquine did not prevent the onset of the depressant respiratory effects of morphine. Chloroquine pretreatment induced a marked increase of the in vitro conjugation of morphine, suggesting that chloroquine acts as a morphine antagonist through a metabolic mechanism. The implication of these effects on morphine tolerance are discussed. © 1969.
Idiomadc.language.isoen
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceEuropean Journal of Pharmacology
Palabras clavesdc.subjectChloroquine
Palabras clavesdc.subjectGlucuronide conjugation
Palabras clavesdc.subjectLethal dose of morphine
Palabras clavesdc.subjectmorphine
Palabras clavesdc.subjectMorphine metabolism
Títulodc.titleEffects of chloroquine pretreatment on lethal dose of morphine and on morphine metabolism in rats
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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