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Authordc.contributor.authorRojas, Eduardo 
Authordc.contributor.authorHidalgo Tapia, María Cecilia 
Cita de ítemdc.identifier.citationBBA - Biochim. Biophys. Acta. I63 (1968) 550-556
Abstractdc.description.abstractLabelled Ca `,+ were incorporated into giant axons froln the squid Dosidicus gigas by immersing them in sea water containing 4'5Ca'-' ~. The washout technique was used and two kinetics for 4SCa2+ outflow were demonstrated (time constants of o.~4o and o.oo5 nfin ~, respectively). The second kinetics of 4sCa °- outflow was greatly affected by temperature and by some metabolic inhibitors. Lowering the temperature of the external sea water resulted in a reduction of the outflow and addition of uncouplers of oxidative phosphorylations or electron transfer inhibitors to the sea water induced an increase in the outflow. Ouabain, at a concentration which has been shown to effectively inhibit Na~ efflux from axons of the same species, does not affect the second kinetics of 4~Cae" outflow. It is claimed here that this second kinetics is related to an intraaxonal compartment and that the rate of this Ca" ~- outflow is determined by a steady state of calciuln uptake and calcium release by some intra-axonal structures.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBBA - Biomembranes
Keywordsdc.subjectCell Biology
Títulodc.titleEffect of temperature and metabolic inhibitors on 45Ca outflow from squid giant axons
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile