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Authordc.contributor.authorChamorro, Hernan 
Authordc.contributor.authorNarvarte, Javier 
Authordc.contributor.authorDiaz, Gabriela 
Authordc.contributor.authorCarpentier, Robert 
Cita de ítemdc.identifier.citationEuropean Journal of Pharmacology, Volumen 30, Issue 1, 2018, Pages 15-22
Abstractdc.description.abstractIn rat isolated right atria, beating spontaneously at 30°C, harmaline 8.3 × 10-5 M slowed atrial rate and enhanced force of contraction. The velocity of development of tension (dT/dt) increased and time to peak tension was lengthened. Electrical drive of otherwise quiescent left atria showed that (1) within the range of change of rate induced by harmaline the reduction of frequency of stimulation increased dT/dt and peak tension developed, and (2) at a constant rate of stimulation harmaline produced a prolongation of time to peak tension and an enhancement of peak tension. We concluded that two mechanisms are responsible for the inotropic action of harmaline on rat atrium: (1) an increase in dT/dt due to the lengthening of the interval between beats; (2) a direct action of harmaline on the processes responsible for atrial contraction, which determines a lengthening of time to peak tension. © 1975.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceEuropean Journal of Pharmacology
Keywordsdc.subjectAtrial force of contraction
Keywordsdc.subjectFrequency dependence of contraction
Keywordsdc.subjectInotropic action
Keywordsdc.subjectIsolated rat atrium
Títulodc.titleThe effect of harmaline on force of contraction of the rat isolated atrium
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile