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Author | dc.contributor.author | Carpenter, Robert | |
Author | dc.contributor.author | Diaz, Gabriela | |
Admission date | dc.date.accessioned | 2019-01-29T15:45:57Z | |
Available date | dc.date.available | 2019-01-29T15:45:57Z | |
Publication date | dc.date.issued | 1977 | |
Cita de ítem | dc.identifier.citation | European Journal of Pharmacology, Volumen 42, Issue 2, 2018, Pages 131-138 | |
Identifier | dc.identifier.issn | 00142999 | |
Identifier | dc.identifier.other | 10.1016/0014-2999(77)90352-1 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/162282 | |
Abstract | dc.description.abstract | The effect of harmaline (HME) was analyzed in rat strips superfused in vitro. A dual inotropic action was found: the positive component was due to a transient catechol-mediated enhancement of the velocity of development of tension (dT/dt) and to a prolongation of the duration of the rising phase of the contraction (TPT). The negative component was due to a depression of dT/dt, which overcame the persistent TPT-prolonging effect of HME, and it was abolished by rising the [K]0. It is concluded that: (1) the positive inotropic effect of HME depends on its actions on the dT/dt and TPT; (2) the enhancement of dT/dt is due to an adrenergic mechanism, which stimulates the Ca2+-dependent slowly activated current (Is); (3) a negative inotropic effect becomes evident whenever the dT/dt is depressed by the drug, regardless of the persistence of the TPT-prolonging effect; (4) the depression of the dT/dt is not due to an inhibition of Is. © 1977. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | European Journal of Pharmacology | |
Keywords | dc.subject | Adrenergic mechanisms | |
Keywords | dc.subject | Atrial force of contraction | |
Keywords | dc.subject | Harmaline | |
Keywords | dc.subject | Inotropic action | |
Keywords | dc.subject | Isolated rat atrium | |
Keywords | dc.subject | Norepinephrine | |
Keywords | dc.subject | Propanolol | |
Título | dc.title | Dual inotropic effect of harmaline on the rat heart atrial muscle | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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