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Effects of 4-aminopyridine on pacemaker activity of frog sinus venosus

Authordc.contributor.authorGuerrero, Sergio 
Authordc.contributor.authorNovakovic, Ljubica 
Admission datedc.date.accessioned2019-01-29T15:46:10Z
Available datedc.date.available2019-01-29T15:46:10Z
Publication datedc.date.issued1980
Cita de ítemdc.identifier.citationEuropean Journal of Pharmacology, Volumen 62, Issue 4, 2018, Pages 335-340
Identifierdc.identifier.issn00142999
Identifierdc.identifier.other10.1016/0014-2999(80)90101-6
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/162355
Abstractdc.description.abstractThe effects of low concentrations of 4-aminopyridine (4-AP) were studied on the frog sinus venosus by means of intracellular microelectrodes. 4-AP depressed spontaneous automaticity. This effect was not reversed by atropine. 4-AP also prolonged the sinus action potential repolarization and slowed the rate of diastolic depolarization. These effects are attributed to blockade of potassium conductance. © 1980.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceEuropean Journal of Pharmacology
Keywordsdc.subject4-Aminopyridine
Keywordsdc.subjectAction potential repolarization
Keywordsdc.subjectFrog sinus venosus
Keywordsdc.subjectSinus venosus automaticity
Títulodc.titleEffects of 4-aminopyridine on pacemaker activity of frog sinus venosus
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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