Active acromegaly and gigantism: some clinical characteristics of 50 patients Acromegalia y gigantismo activos:algunas características clínicas de 50 pacientes.
Author
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Pumarino, Diego
Author
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Oviedo,
Author
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Michelsen,
Author
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Campino,
Admission date
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2019-01-29T15:47:42Z
Available date
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2019-01-29T15:47:42Z
Publication date
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1991
Cita de ítem
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Revista medica de Chile, Volumen 119, Issue 8, 2018, Pages 897-907
Identifier
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00349887
Identifier
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https://repositorio.uchile.cl/handle/2250/162451
Abstract
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50 patients with autonomous growth hormone excess (48 with adult acromegaly and 2 with gigantism) were studied between 1966 to 1986 (2.38 pts/year). Characteristic clinical presentation, an increase in growth hormone (GH) uninhibited by glucose, and/or hyperphosphemia and hyperhydroxiprolinuria were present in all patients. No cases of hypercalcemia were recorded. Phosphemia was increased in 55.8%, alkaline phosphatases in 61.7%, calciuria in 26.9% and hydroxyprolinuria in 74.2% of the patients. Basal GH was over 5 ng/ml (89.9 DS +/- 170.9) in 42 pts, and in 37 was not suppressed after glucose administration, 38% had an increased (paradoxical response) and 62% a flat response (less than 50% change of basal values). TRH test was performed in 14 patients, 8 presented an increase in GH titer. Hyperprolactinemia was seen in 4 of 12 patients in whom this hormone was measured. The size of the sella turcica was increased in 93%, and although the larger sellar size correlated to higher levels
Active acromegaly and gigantism: some clinical characteristics of 50 patients Acromegalia y gigantismo activos:algunas características clínicas de 50 pacientes.