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Authordc.contributor.authorDíaz Díaz, Marcela Cecilia 
Authordc.contributor.authorChaná, 
Admission datedc.date.accessioned2019-01-29T15:47:42Z
Available datedc.date.available2019-01-29T15:47:42Z
Publication datedc.date.issued1991
Cita de ítemdc.identifier.citationRevista medica de Chile, Volumen 119, Issue 9, 2018, Pages 1022-1028
Identifierdc.identifier.issn00349887
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/162455
Abstractdc.description.abstractTen advanced Parkinson pts (mean 8 years since diagnosis), 6 male and 4 female, 57 to 69 years old, mean 5.9 years on L-Dopa therapy, were put on Madopar HBS to assess the efficacy of the drug. All the pts had levodopa end-of-dose wearing-off type secondary motor fluctuations, 9 of them with dyskinesia and dystonia. Clinical evaluation was performed in basal conditions (pts on standard L-Dopa therapy) 1.6 and 12 months on Madopar HBS therapy. Parkinson signology was quantified with the modified Columbia scale (0 to 44), and motor fluctuations and dyskinesia with a scale 0 to 4 according to intensity and frequency. Pts received mean 1.150 mg. HBS daily dose plus 100 to 200 mg standard L-Dopa added to the early morning dose for a faster effect. At 12 months, a 60% decrease in "off" periods, a 50% decrease in feet dystonia, with no change in orofacial dystonia were observed. Dyskinesia decreased in intensity but not in frequency. There was a 50% decrease of Parkinson signology in "on" per
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceRevista medica de Chile
Keywordsdc.subjectMedicine (all)
Títulodc.titleLevodopa and controlled release benserazide in the handling of motor fluctuations in Parkinson's disease Levodopa más benserazida de liberación controlada en el manejo de lasfluctuaciones motoras en la enfermedad de Parkinson.
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile