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Authordc.contributor.authorReyes Parada, Miguel 
Authordc.contributor.authorScorza, Ma. Cecilia 
Authordc.contributor.authorSilveira, Rodolfo 
Authordc.contributor.authorDajas, Federico 
Authordc.contributor.authorCosta, Gustavo 
Authordc.contributor.authorTipton, keith F. 
Authordc.contributor.authorCassels Niven, Bruce 
Admission datedc.date.accessioned2019-01-29T15:49:53Z
Available datedc.date.available2019-01-29T15:49:53Z
Publication datedc.date.issued1994
Cita de ítemdc.identifier.citationBiochemical Pharmacology, Volumen 47, Issue 8, 2018, Pages 1365-1371
Identifierdc.identifier.issn00062952
Identifierdc.identifier.other10.1016/0006-2952(94)90335-2
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/162472
Abstractdc.description.abstractThe in vitro and ex vivo monoamine oxidase (MAO) inhibitory effects of (±)4-dimethylamino-α-methyl-phenethylamine 4-DMAA) and (±)4-methylamino-α-methyl-phenethylamine (4-MAA) were reassessed, in comparison with the previously unstudied achiral parent compound, 4-dimethyl-aminophenethylamine (4-DMAPEA) and with a salt of 4-DMAA enriched in the levo isomer, ("-")-4-DMAA, using amiflamine [S-(+)-4-dimethylamino-α,2-dimethylphenethylamine] as positive control. The in vitro studies confirmed that 4-amino-α-methylphenethylamine derivatives are highly selective and reversible MAO-A inhibitors. Furthermore, ("-")-4DMAA was less active than the racemic mixture. The side chain-unsubstituted compound, 4-DMAPEA, proved to be a nonselective and reversible MAO inhibitor. The ex vivo results, in which catecholamines, serotonin (5-HT) and their metabolites were measured in two brain regions after i.p. administration, confirmed the results obtained in vitro. These results are consistent with the sugges
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiochemical Pharmacology
Keywordsdc.subjectantidepressants
Keywordsdc.subjectphenylethylamine derivatives
Keywordsdc.subjectphenylisopropylamine derivatives
Keywordsdc.subjectstereo-selectivity
Títulodc.titleMonoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile