Ethnic segregation of HTLV‐I and HTLV‐II carriers among South American native Indians
Author
dc.contributor.author
Fujiyoshi, Toshinobu
Author
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Yashiki, Shinji
Author
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Fujiyama, Chihaya
Author
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Kuwayama, Masahiro
Author
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Miyashita, Hiroki
Author
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Ohnishi, Hiroshi
Author
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Blank, Michelle
Author
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Zaninovic, Vladimir
Author
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Blank, Abraham
Author
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Cartier Rovirosa, Luis
Author
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Byrnes, John J.
Author
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Harrington, William J.
Author
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Miura, Tomoyuki
Author
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Hayami, Masanori
Author
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Tajima, K
Admission date
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2019-01-29T15:50:08Z
Available date
dc.date.available
2019-01-29T15:50:08Z
Publication date
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1995
Cita de ítem
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International Journal of Cancer, Volumen 63, Issue 4, 2018, Pages 510-515
Identifier
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10970215
Identifier
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00207136
Identifier
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10.1002/ijc.2910630409
Identifier
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https://repositorio.uchile.cl/handle/2250/162566
Abstract
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Thd investigate the genetic background of human T‐cell leukemia virus type I (HTLV‐I) and II (HTLV‐IIhd carriers among South American native Indians, we analyzed HLA DRBI*‐DQBI * haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR‐RFLP genotyping method. It was revealed that the HTLV‐I‐carrying Andes natives had one of the 5 HLA haplotypes: DRBI*‐DQBI* 0403‐0302, 0802‐0402, 0901‐0303, 1406‐0302 and 0407‐0302, and that the Orinoco HTLV‐II carriers had one of the 3 HLA haplotypes: DRBI*‐DQBI* 1402‐0301, 1602‐0301 and 0404‐0302. The HLA haplotypes of Andes HTLV‐I carriers and Orinoco HTLV‐II carriers were mutually exclusive. The haplotypes associated with HTLV‐I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV‐I endemic population, while the haplotypes associated with HTLV‐II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV‐II is endemic. These reults suggested