Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy
Author
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Meng, Ling Jie
Author
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Reyes, Humberto
Author
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Palma, Jonquin
Author
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Hernandez, Ismael
Author
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Ribalta, José
Author
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Sjövall, Jan
Admission date
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2019-01-29T15:54:56Z
Available date
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2019-01-29T15:54:56Z
Publication date
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1997
Cita de ítem
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Journal of Hepatology, Volumen 27, Issue 6, 2018, Pages 1029-1040
Identifier
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01688278
Identifier
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10.1016/S0168-8278(97)80147-X
Identifier
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https://repositorio.uchile.cl/handle/2250/162738
Abstract
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Background/Aims and Methods: The mechanism(s) behind the effects of ursodeoxycholic acid on serum steroid sulphate profiles in patients with intrahepatic cholestasis of pregnancy is not clear. Conjugated progesterone metabolites and bile acids have therefore been analysed in serum and urine of patients with intrahepatic cholestasis of pregnancy before and during treatment with ursodeoxycholic acid using chromatographic and mass spectrometric methods. Results: The concentration of glycine-/taurine- conjugated bile acids decreased from 8.9±3 μmol/l (mean± SEM) before treatment to 1.8±0.6 μmol/l during treatment with ursodeoxycholic acid. The total bile acid excretion in urine decreased from 56±14 to 32±5.6 μmol/g creatinine. The proportion of cholic acid in serum and urine, and of 1β-, 2β- and 6α-hydroxylated cholic acids in urine decreased markedly during ursodeoxycholic acid while the percentages of 3α,12α-dihydroxy-3-oxo-4- cholenoic acid and chenodeoxycholic acid were unchanged. The
Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy