Recent progress in understanding aldosterone secretion
Author
dc.contributor.author
Foster, Richard H.
Author
dc.contributor.author
MacFarlane, Catriona H.
Author
dc.contributor.author
Bustamante, Mirta O.
Admission date
dc.date.accessioned
2019-01-29T15:55:03Z
Available date
dc.date.available
2019-01-29T15:55:03Z
Publication date
dc.date.issued
1997
Cita de ítem
dc.identifier.citation
General Pharmacology, Volumen 28, Issue 5, 2018, Pages 647-651
Identifier
dc.identifier.issn
03063623
Identifier
dc.identifier.other
10.1016/S0306-3623(96)00290-X
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/162769
Abstract
dc.description.abstract
1. The synthesis and secretion of aldosterone in the adrenal zona glomerulosa in physiologic conditions is controlled by adrenocorticotropin (ACTH), angiotensin II (AII), and extracellular (K+). 2. ACTH effects on aldosterone output are explained by cyclic AMP- (cAMP)- and Ca2+-dependent mechanisms. 3. All effects on aldosterone secretion are initiated by an increase in Ca2+ influx through hormoneoperated Ca2+ channels and G- protein- and phospholipase C- (PLC) dependent hydrolysis of phosphoinositides leading to the generation of inositol 1,4,5 trisphosphate (IP3) and DAG that induce intracellular Ca2+ release and PKC activation, respectively. 4. ACTH increases DAG formation with marginal or undetectable IP3 generation. The effect of ACTH on DAG levels is discussed. 5. The requirement of external Ca2+ in PLC activation and aldosterone secretion also is discussed.