Hormonal profile, endometrial histology and ovarian ultrasound assessment during 1 year of nomegestrol acetate implant (Uniplant®)
Author
dc.contributor.author
Devoto, Luigi
Author
dc.contributor.author
Kohen Skop, Paulina
Author
dc.contributor.author
Barnhart, Kurt
Author
dc.contributor.author
Alba, Francisco
Author
dc.contributor.author
Pommer, Ricardo
Author
dc.contributor.author
Retamales, Ivan
Author
dc.contributor.author
Coutinho, Elzimar
Admission date
dc.date.accessioned
2019-01-29T15:55:03Z
Available date
dc.date.available
2019-01-29T15:55:03Z
Publication date
dc.date.issued
1997
Cita de ítem
dc.identifier.citation
Human Reproduction, Volumen 12, Issue 4, 2018, Pages 708-713
Identifier
dc.identifier.issn
02681161
Identifier
dc.identifier.other
10.1093/humrep/12.4.708
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/162771
Abstract
dc.description.abstract
The present study assesses the endocrinological, endometrial histology and vaginal ultrasound profiles of nomegestrol acetate subdermal implant users at varying times after insertion. Follicle stimulatory hormone, luteinizing hormone, oestradiol, progesterone, vaginal ultrasound assessment of the ovaries and the histological dating of the endometrium were serially assessed for a period of 50 days immediately after the insertion, and after at 6 months and 12 months of use. The endocrinological results of this prospective observational clinical trial indicated that 75% of the cycles across the study period in Uniplant® users were anovulatory, 63% showing development of a persistent non-luteinized follicle. Anovulatory cycles devoid of follicular development were seen primarily in the first months after Uniplant insertion. Ovulatory cycles represented 25% of the Uniplant cycles. Inadequate luteal phase or disregulation of follicular growth was a common feature of ovulatory cycles. In conc