Vascular smooth muscle reactivity to norepinephrine in ovariectomized rats: Relationship to vascular PGE2/PGF2α ratio
Author
dc.contributor.author
Zamorano, B.
Author
dc.contributor.author
Bruzzone Valdés, María Eugenia
Author
dc.contributor.author
Martinez, J. L.
Admission date
dc.date.accessioned
2019-01-29T16:00:02Z
Available date
dc.date.available
2019-01-29T16:00:02Z
Publication date
dc.date.issued
1995
Cita de ítem
dc.identifier.citation
General Pharmacology, Volumen 26, Issue 7, 2018, Pages 1613-1618
Identifier
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03063623
Identifier
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10.1016/0306-3623(95)00060-7
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163020
Abstract
dc.description.abstract
1. 1. We have recently demonstrated that, in normal female rats, vascular reactivity (VR) and vascular prostaglandin-E2 (PGE2) and prostacyclin production are influenced by the ovarian cycle. 2. 2. In this study, we investigated the vascular reactivity (VR) of isolated rat thoracic aorta to norepinephrine (NE 10-12-10-6M) in ovariectomized rats (OVX-rats), 48 hr and 8 days after surgical removal of the ovaries and in normally cycling rats (NR) at the proestrus stage of the estrous cycle, when the level of circulating estrogen was higher. 3. 3. In addition, we determined the vascular synthesis of PGE2 and protaglandin-F2α (PGF2α) in both groups of OVX-rats, and in NR during the proestrous stage. 4. 4. The results showed that VR to NE 10-12-10-10 M was similar between OVX-rats and normal rats. 5. 5. However, aortic rings obtained from both groups of OVX-rats showed a significant increase of the contraction response induced by NE 10-9-10-6 M. 6. 6. Furthermore, the contractile response to