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Authordc.contributor.authorDissen, Gregory A. 
Authordc.contributor.authorHill, Diane F. 
Authordc.contributor.authorCosta, Maria E. 
Authordc.contributor.authorLes Dees, W. 
Authordc.contributor.authorLara Peñaloza, Hernán 
Authordc.contributor.authorOjeda, Sergio R. 
Cita de ítemdc.identifier.citationEndocrinology, Volumen 137, Issue 1, 2018, Pages 198-209
Abstractdc.description.abstractSeveral members of the neurotrophin (NT) family, including nerve growth factor (NGF), NT-3, and NT-4/5, are expressed in the mammalian ovary. As their respective receptor tyrosine kinases are also found in the gland, the possibility exists that NTs act directly on the gonads to exert effects unrelated to their support of the ovarian innervation. We now report that trkA, the NGF receptor tyrosine kinase, is involved in the acute activational process that leads to the first ovulation. The trkA gene becomes transiently expressed in periovulatory follicles at the time of the first preovulatory surge of gonadotropins at puberty; the increase in trkA messenger RNA (mRNA) con tent is dramatic (>100-fold), but transient (~9 h). No such changes in trkB or trkC mRNA were observed; the abundance of these mRNAs, which encode the receptor tyrosine kinases for NT-4/5 and brain-derived neurotrophic factor, and NT-3, respectively, remained at very low levels throughout puberty. In vivo and in vitro ex
Publisherdc.publisherEndocrine Society
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Títulodc.titleA role for TrkA nerve growth factor receptors in mammalian ovulation
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile