Limits of metabolic tolerance to copper and biological basis for present recommendations and regulations
Author
dc.contributor.author
Olivares, Manuel
Author
dc.contributor.author
Uauy Dagach-Imbarack, Ricardo
Admission date
dc.date.accessioned
2019-01-29T16:00:11Z
Available date
dc.date.available
2019-01-29T16:00:11Z
Publication date
dc.date.issued
1996
Cita de ítem
dc.identifier.citation
American Journal of Clinical Nutrition, Volumen 63, Issue 5, 2018,
Identifier
dc.identifier.issn
00029165
Identifier
dc.identifier.other
10.1093/ajcn/63.5.846
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163053
Abstract
dc.description.abstract
Acute copper toxicity is infrequent in humans. The evidence for chronic toxicity is derived principally from patients with Wilson disease and cases of infantile cirrhosis that were related to excessive copper intakes. The evaluation of the safety of a nutrient requires toxicologic studies to determine the limits of safe exposure. The acceptable daily intake (ADI) is calculated by determining the highest no-observed-adverse-effect level (NOAEL). When it is not possible to identify the NOAEL, the lowest observed- adverse-effect level (LOAEL) may be used. For the calculation of the human ADI, the NOAEL or LOAEL obtained is divided by an arbitrary safety factor to provide an adequate margin of security. Drinking water standards have been adopted by the United States, the European Community, the World Health Organization, and other countries. The upper limits of copper concentration in water are based on organoleptic considerations and on debatable toxicity information. Given the importance