Developmental changes and differential regulation by testosterone and estradiol of growth hormone receptor expression in the rabbit
Author
dc.contributor.author
Yu, Yu M.
Author
dc.contributor.author
Domené, Horacio M.
Author
dc.contributor.author
Sztein, Jorge
Author
dc.contributor.author
Counts, Debra R.
Author
dc.contributor.author
Cassorla Goluboff, Fernando
Admission date
dc.date.accessioned
2019-01-29T16:00:13Z
Available date
dc.date.available
2019-01-29T16:00:13Z
Publication date
dc.date.issued
1996
Cita de ítem
dc.identifier.citation
European Journal of Endocrinology, Volumen 135, Issue 5, 2018, Pages 583-590
Identifier
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08044643
Identifier
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10.1530/eje.0.1350583
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163060
Abstract
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To investigate the effects of testosterone and estradiol (E2) on growth hormone receptor (GH-R) gene expression, we measured GH-R mRNA levels in relation to the changes of sex steroid concentrations in the normal male rabbits aged 1-12 months and after administration of testosterone or E2 to castrated male rabbits. In the normal animals. E2 levels were below the detection limit in all age groups, and testosterone levels were below the detection limit at 1 month, increased at 2 months and reached the plateau of the adult levels after 4 months. Liver GH-R mRNA levels were low at 1 month, reached a peak at 2 months and then decreased slightly thereafter. In the castrated animals, liver and growth plate GH-R mRNA levels were increased in the testosterone-treated group (162.0 ± 12.0%, p <0.025; 128.4 ± 7.6%; p< 0.025) and reduced in the E2-treated group (29.6 ± 6.2%, p < 0.005; 53.6 ± 11.3%, p < 0.025). Sex steroid administration did not result in any significant change in GH-R mRNA levels