Placentae of fetuses with chromosome 16 trisomy: A morphometric analysis of the interchange chorionic villi
Author
dc.contributor.author
Dominguez, Susana A.
Author
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Be, Cecilia
Author
dc.contributor.author
Ayarza, Eliana
Author
dc.contributor.author
Angelica Montenegro, M.
Admission date
dc.date.accessioned
2019-01-29T17:15:47Z
Available date
dc.date.available
2019-01-29T17:15:47Z
Publication date
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1998
Cita de ítem
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Medical Science Research, Volumen 26, Issue 8, 2018, Pages 507-509
Identifier
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02698951
Identifier
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https://repositorio.uchile.cl/handle/2250/163327
Abstract
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We have studied chorionic villi from 38 placentae obtained from spontaneous abortions at 7 to 12 weeks of pregnancy. Samples were separated into four groups: (1) early normal (7-9 weeks of pregnancy, normal karyotype); (2) late normal (10-12 weeks of pregnancy, normal karyotype); (3) early trisomic (7-9 weeks of pregnancy, trisomy 16 karyotype); and (4) late trisomic (10-12 weeks of pregnancy, trisomy 16 karyotype). Villous area trophoblastic area, stromal area and cell density were analysed through morphometric studies in serial sections. These were stained with haematoxylin-eosin-Alcian blue, picrosirius and diastase-periodic acid Schiff techniques. Early trisomic villi were not overtly different from normal karyotype villi. In contrast, late trisomy 16 chorionic villi had a smaller area, and the chorionic mesenchyme showed lower collagen and cell density. The morphological differences in villi described here could suggest an inability to maintain normal rates of proliferation and me