Presence of angiotensin II and expression of angiotensin II type-2 receptor in human fallopian tube

Abstract

Objective: To determine the presence of angiotensin II and angiotensin II type-2 receptor subtype messenger RNA (mRNA) in human fallopian tube. Design: Frozen fallopian tubes were used for all studies. Setting: Procedures were performed at the Institute of Maternal and Child Research, School of Medicine, University of Chile and San Borja-Arriaran Clinical Hospital, National Health Service, Santiago, Chile. Patient(s): Eight patients (30-38 years) undergoing surgical sterilization or hysterectomy for benign gynecologic conditions. Intervention(s): Surgery was scheduled in the proliferative or secretory stage of the menstrual cycle. Main Outcome Measure(s): Localization of angiotensin II by immunofluorescence studies, expression of angiotensin II type-2 receptor mRNA, and concentrations of angiotensin II receptor subtypes and binding characteristics. Result(s): Angiotensin II was immunolocalized mainly in blood vessel endothelium and, to a lesser extent, in stromal cells. Both binding an