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Authordc.contributor.authorFernández Arancibia, Virginia 
Authordc.contributor.authorCornejo, Pamela 
Authordc.contributor.authorTapia Opazo, Gladys 
Authordc.contributor.authorVidela Cabrera, Luis 
Cita de ítemdc.identifier.citationNitric Oxide - Biology and Chemistry, Volumen 1, Issue 6, 2018, Pages 463-468
Abstractdc.description.abstractHyperthyroidism enhances the prooxidant activity of the liver by elevating superoxide radical and/or hydrogen peroxide generation in microsomal, mitochondrial, and peroxisomal fractions, with an increased respiratory burst of Kupffer cells. In this study, the influence of daily doses of 0.1 mg 3,3',5-triiodothyronine (T3)/kg for three consecutive days on liver nitric oxide (NO) synthase (NOS) was assessed, as a possible contributory mechanism to T3-induced liver prooxidant activity. Thyroid calorigenesis was paralleled by a progressive increment in the rate of NO generation, with significant increases after 2 (47%) and 3 days (70%) of T3 treatment, and a net 45% (P < 0.05) enhancement in the N(G)-methyl-Larginine-sensitive NO production, compared to control values. These enhancement effects were reversed to control levels after 3 days of hormone withdrawal, concomitantly with the normalization of hepatic respiration. Enhancement of liver NOS activity in hyperthyroid Animals was diminis
Publisherdc.publisherAcademic Press Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceNitric Oxide - Biology and Chemistry
Keywordsdc.subjectHepatic nitric oxide synthase
Keywordsdc.subjectKupffer cells
Keywordsdc.subjectLiver oxidative stress
Títulodc.titleInfluence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile