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Authordc.contributor.authorWyneken, U. 
Authordc.contributor.authorSmalla, K. H. 
Authordc.contributor.authorMarengo, J. J. 
Authordc.contributor.authorSoto, D. 
Authordc.contributor.authorDe la Cerda, A. 
Authordc.contributor.authorTischmeyer, W. 
Authordc.contributor.authorGrimm, R. 
Authordc.contributor.authorBoeckers, T. M. 
Authordc.contributor.authorWolf, G. 
Authordc.contributor.authorOrrego, F. 
Authordc.contributor.authorGundelfinger, E. D. 
Admission datedc.date.accessioned2019-01-29T17:50:52Z
Available datedc.date.available2019-01-29T17:50:52Z
Publication datedc.date.issued2001
Cita de ítemdc.identifier.citationNeuroscience, Volumen 102, Issue 1, 2018, Pages 65-74
Identifierdc.identifier.issn03064522
Identifierdc.identifier.other10.1016/S0306-4522(00)00469-3
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/163452
Abstractdc.description.abstractThe postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainate injection, the protein content of the postsynaptic density fractions from rats that developed strong seizures was increased three-fold compared to saline-treated controls. Immunoblot analysis revealed that the relative amounts of metabotropic glutamate receptor 1α, N-ethylmaleimide-sensitive fusion protein, protein kinases C, Fyn and TrkB, as well as the neuronal nitric oxide synthase, were significantly higher in seizure-developing than in control rats. In contrast, the relative contents of the kainate receptor KA2 subunit, β-actin, α-adducin and the membrane-associated guanylate kinase homolog SAP90/PSD-95 were decreased. The relative amounts of additional postsynaptic
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceNeuroscience
Keywordsdc.subjectEpilepsy
Keywordsdc.subjectGlutamate receptor
Keywordsdc.subjectProtein kinases
Keywordsdc.subjectSAP90/PSD-95
Keywordsdc.subjectSynapse
Keywordsdc.subjectSynaptic plasticity
Títulodc.titleKainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile