Show simple item record

Authordc.contributor.authorCornejo, Pamela 
Authordc.contributor.authorTapia Opazo, Gladys 
Authordc.contributor.authorPuntarulo, Susana 
Authordc.contributor.authorGalleano, Mónica 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorFernández Arancibia, Virginia 
Cita de ítemdc.identifier.citationToxicology Letters, Volumen 119, Issue 2, 2018, Pages 87-93
Abstractdc.description.abstractThe involvement of cytosolic nitric oxide (NO) and mitochondrial superoxide radical (O2 ·-) production was evaluated as a mechanism triggering liver oxidative stress in lindane (40 mg/kg) or L-3,3′,5-triiodothyronine (T3, 0.1 mg/kg for 2 consecutive days) treated animals (male Sprague-Dawley rats) subjected to iron overload (200 mg/kg). Lindane and iron led to 504 and 210% increases in the content of hepatic protein carbonyls as an index of oxidative stress, with a 706% enhancement being produced by their combined administration. T3 did not alter this parameter, whereas iron overload increased the content of protein carbonyls by 116% in hyperthyroid rats. Lindane increased NO generation by 106% without changes in generation of O2 ·-, whereas iron enhanced both parameters by 109 and 80% over control values, respectively, with a net 33 and 46% decrease, respectively, being elicited by the combined treatment related to iron overload alone. Hyperthyroidism increased liver NO (69%) and O2 ·
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceToxicology Letters
Keywordsdc.subjectIron overload
Keywordsdc.subjectNitric oxide
Keywordsdc.subjectRat liver
Keywordsdc.subjectSuperoxide radical
Keywordsdc.subjectThyroid hormone
Títulodc.titleIron-induced changes in nitric oxide and superoxide radical generation in rat liver after lindane or thyroid hormone treatment
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile