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Authordc.contributor.authorGomes, L. F. 
Authordc.contributor.authorGonçalves, L. M. 
Authordc.contributor.authorFonseca, F. L.A. 
Authordc.contributor.authorCelli, C. M. 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorChaimovich, H. 
Authordc.contributor.authorJunqueira, Virginia 
Cita de ítemdc.identifier.citationFree Radical Research, Volumen 36, Issue 7, 2018, Pages 741-747
Abstractdc.description.abstractβ2-Glycoprotein I (β2GPI) is known to influence macrophage uptake of particles with phosphatidylserine containing surfaces, as apoptotic thymocytes and unilamellar vesicles in vitro. Nevertheless, effects upon macrophage activation induced by this interaction are still unknown. β2GPI influence upon the reactive species production by Kupffer cells was evaluted in order to investigate whether β2GPI modulates the macrophage response to negatively charged surfaces. Chemiluminescence of isolated non-parenchymal rat liver cells was measured after phagocytosis of opsonized zymosan or phorbolmyristate acetate (PMA) stimulation, in the presence and absence of large unilamellar vesicles (LUVs) containing 25 mol% phosphatidylserine (PS) or 50 mol% cardiolipin (CL) and complementary molar ratio of phosphatidylcholine (PC). β2GPI decreased by 50% the chemiluminescence response induced by opsonized zymosan, with a 66% reduction of the initial light emission rate. PMA stimulated Kupffer cell chemilum
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFree Radical Research
Keywordsdc.subjectApolipoprotein H (β2-glycoprotein I)
Keywordsdc.subjectKupffer cell
Keywordsdc.subjectMacrophage activation
Keywordsdc.subjectPhospholipid vesicles
Títulodc.titleβ2-glycoprotein I (apolipoprotein H) modulates uptake and endocytosis associated chemiluminescence in rat Kupffer cells
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile