Toxicokinetics and toxicodynamics of gonyautoxins after an oral toxin dose in cats
Author
dc.contributor.author
Andrinolo, Darío
Author
dc.contributor.author
Iglesias, Verónica
Author
dc.contributor.author
García, Carlos
Author
dc.contributor.author
Lagos, Néstor
Admission date
dc.date.accessioned
2019-01-29T17:51:07Z
Available date
dc.date.available
2019-01-29T17:51:07Z
Publication date
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2002
Cita de ítem
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Toxicon, Volumen 40, Issue 6, 2018, Pages 699-709
Identifier
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00410101
Identifier
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10.1016/S0041-0101(01)00263-X
Identifier
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https://repositorio.uchile.cl/handle/2250/163506
Abstract
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Although the action of Gonyautoxins (GTXs) and Saxitoxin (STX) mechanisms is well known at the molecular level, there are still many unresolved questions associated with the intoxication syndrome in mammals. For example, how are these toxins absorbed in the digestive system? Where are they absorbed? What is the absorption rate? What is the maximal concentration in plasma (Cmax) and the time taken to reach this Cmax (Tmax) in the case of oral toxin administration? These questions are addressed in this paper, which describes an experimental design which allowed us to follow the toxicokinetics and toxicodynamics of GTX 2/3 epimers poisoning in vivo, when an oral dose of toxin was administered to an anaesthetized cat permanently coupled to an artificial ventilator. The GTX 2/3 epimers was orally administered with a dose of 70μg/kg, then urine and blood samples were collected during a 5h experimental period. The toxins were quantified using a post column derivatisation high performance liqu