Interstitial thermal therapy in patients with localized prostate cancer: Histologic analysis
Author
dc.contributor.author
Tucker, Robert D.
Author
dc.contributor.author
Platz, Charles E.
Author
dc.contributor.author
Huidobro, Christian
Author
dc.contributor.author
Larson, Thayne
Admission date
dc.date.accessioned
2019-01-29T17:51:07Z
Available date
dc.date.available
2019-01-29T17:51:07Z
Publication date
dc.date.issued
2002
Cita de ítem
dc.identifier.citation
Urology, 60: 166–169, 2002
Identifier
dc.identifier.issn
00904295
Identifier
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10.1016/S0090-4295(02)01653-9
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163510
Abstract
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Objectives. To examine, by way of histologic examination, the destruction of excised prostate glands
treated with thermal ablation. Thermal ablation treatment with permanently implanted temperature selfregulating
rods is being used in the treatment of localized prostate cancer.
Methods. Four patients with biopsy-proven prostate cancer, who had been scheduled for routine radical
prostatectomy with a gland size of less than 70 g, Gleason sum of 7 or less, and prostate-specific antigen
values less than 10.0 ng/mL, were implanted with 70°C rods under ultrasound and fluoroscopic control. The
patients were then given multiple thermal treatments. Glands were removed and histologically analyzed to
access the thermal destruction.
Results. Histologic examination revealed confluent thermal destruction within the rod array when the rods
were placed end-to-end and no farther than 1 cm apart. Little necrosis was seen outside the array. To ensure
the necessary destruction, the rods must be placed at the capsule, including posteriorly near the rectum. The
results indicated that energy levels greater than 40 W-min/g of tissue should be used. This can be achieved
by implanting 1.5 rods/g of prostate and treating the patient for 60 minutes. In 3 of the 4 patients, no
residual cancer was found in the gland after thermal treatment.
Conclusions. Histologic examination has aided in determining the implant density and treatment time and,
therefore, the necessary energy, for adequate necrosis. The technique demonstrates the ability to destroy
the prostate adequately, including tissue at the capsule. This new procedure appears promising in the
treatment of localized prostate cancer.