Introduction to supramolecular complex formation in cell signaling and disease

Abstract

In summary, formation of multi-protein complexes is an essential if not defining feature of eukaryotic signaling. Clearly, we now appreciate this fact and are beginning to grasp some of the underlying guiding principles. However, much remains yet to be accomplished. The hope is that insights to these mechanisms will not only further our understanding of fundamental processes in biology like signal transduction, but will also help in the development of new strategies to treat human disease.