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Authordc.contributor.authorFelley-Bosco, Emanuela 
Authordc.contributor.authorBender, Florent 
Authordc.contributor.authorQuest, Andrew F. G. 
Admission datedc.date.accessioned2019-01-29T17:51:10Z
Available datedc.date.available2019-01-29T17:51:10Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationBiological Research, Volumen 35, Issue 2, 2018, Pages 169-176
Identifierdc.identifier.issn07169760
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/163522
Abstractdc.description.abstractReactive oxygen species are now widely recognized as important players contributing both to cell homeostasis and the development of disease. In this respect nitric oxide (NO) is no exception. The discussion here will center on regulation of the inducible form of nitric oxide synthase (iNOS) for two reasons. First, only iNOS produces micromolar NO concentrations, amounts that are high by comparison with the picomolar to nanomolar concentrations resulting from Ca2+-controlled NO production by endothelial eNOS or neuronal nNOS. Second, iNOS is not constitutively expressed in cells and regulation of this isoenzyme, in contrast to endothelial eNOS or neuronal nNOS, is widely considered to occur at the transcriptional level only. In particular, we were interested in the possibility that caveolin-1, a protein that functions as a tumor suppressor in colon carcinoma cells (Bender et al., 2002; this issue), might regulate iNOS activity. Our results provide evidence for the existence of a post-tr
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiological Research
Keywordsdc.subjectCaveolae
Keywordsdc.subjectCaveolin-1
Keywordsdc.subjectCytokines
Keywordsdc.subjectInducible nitric oxide synthase
Keywordsdc.subjectNitroxysomes
Keywordsdc.subjectProteosome-mediated proteolysis
Títulodc.titleCaveolin-1-mediated post-traditional regulation of inducible nitric oxide synthase in human colon carcinoma cells
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile