Neostigmine interactions with non steroidal anti-inflammatory drugs
Author
dc.contributor.author
Miranda, Hugo F.
Author
dc.contributor.author
Sierralta, Fernando
Author
dc.contributor.author
Pinardi, Gianni
Admission date
dc.date.accessioned
2019-01-29T17:51:52Z
Available date
dc.date.available
2019-01-29T17:51:52Z
Publication date
dc.date.issued
2002
Cita de ítem
dc.identifier.citation
British Journal of Pharmacology, Volumen 135, Issue 7, 2018, Pages 1591-1597
Identifier
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00071188
Identifier
dc.identifier.other
10.1038/sj.bjp.0704599
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163590
Abstract
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1. The common mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) is the inhibition of the enzyme cyclo-oxygenase (COX), however, this inhibition is not enough to completely account for the efficacy of these agents in several models of acute pain. 2. It has been demonstrated that cholinergic agents can induce antinociception, but the nature of the interaction between these agents and NSAIDs drugs has not been studied. The present work evaluates, by isobolographic analysis, the interactions between the cholinergic indirect agonist neostigmine (NEO) and NSAIDs drugs, using a chemical algesiometric test. 3. Intraperitoneal (i.p.) or intrathecal (i.t.) administration of NEO and of the different NSAIDs produced dose-dependent antinociception in the acetic acid writhing test of the mouse. 4. The i.p. or i.t. co-administration of fixed ratios of ED 50 fractions of NSAIDs and NEO, resulted to be synergistic or supra-additive for the combinations ketoprofen (KETO) and NEO, par