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Authordc.contributor.authorMuñoz, Francisco J. 
Authordc.contributor.authorOpazo, Carlos 
Authordc.contributor.authorGil-Gómez, Gabriel 
Authordc.contributor.authorTapia, Gladys 
Authordc.contributor.authorFernández, Virginia 
Authordc.contributor.authorValverde, Miguel A. 
Authordc.contributor.authorInestrosa, Nibaldo C. 
Admission datedc.date.accessioned2019-01-29T17:51:53Z
Available datedc.date.available2019-01-29T17:51:53Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationJournal of Neuroscience, Volumen 22, Issue 8, 2018, Pages 3081-3089
Identifierdc.identifier.issn02706474
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/163599
Abstractdc.description.abstractAmyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called hereditary cerebral hemorrhage with amyloidosis of the Dutch type is caused by a point mutation in Aβ yielding AβGlu22→Gln. The present study addresses the effect of amyloid fibrils from both wild-type and mutated Aβ on vascular cells, as well as the putative protective role of antioxidants on amyloid angiopathy. For this purpose, we studied the cytotoxicity induced by Aβ1-40 Glu22→Gln and Aβ1-40 wild-type fibrils on human venule endothelial cells and rat aorta smooth muscle cells. We observed that AβGlu22→Gln fibrils are more toxic for vascular cells than the wild-type fibrils. We also evaluated the cytotoxicity of Aβ fibrils bound with acetyl-cholinesterase (AChE), a common component of amyloid deposits. Aβ1-40 wild-type-AChE fibrillar complexes, similar to neurona
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Neuroscience
Keywordsdc.subject17β-estradiol
Keywordsdc.subjectAcetylcholinesterase
Keywordsdc.subjectAlzheimer's disease
Keywordsdc.subjectAmyloid
Keywordsdc.subjectCAA
Keywordsdc.subjectEndothelial cells
Keywordsdc.subjectHCHWA-D
Keywordsdc.subjectOxidative stress
Keywordsdc.subjectVascular smooth muscle cells
Keywordsdc.subjectVitamin C
Keywordsdc.subjectVitamin E
Títulodc.titleVitamin E but not 17β-estradiol protects against vascular toxicity induced by β-amyloid wild type and the dutch amyloid variant
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile