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Author | dc.contributor.author | Allen, David D. | |
Author | dc.contributor.author | Cárdenas, Ana María | |
Author | dc.contributor.author | Arriagada, Christian | |
Author | dc.contributor.author | Bennett, Lori B. | |
Author | dc.contributor.author | García, Carlos J. | |
Author | dc.contributor.author | Caviedes, Ral | |
Author | dc.contributor.author | Rapoport, Stanley I. | |
Author | dc.contributor.author | Caviedes, Pablo | |
Admission date | dc.date.accessioned | 2019-01-29T17:51:55Z | |
Available date | dc.date.available | 2019-01-29T17:51:55Z | |
Publication date | dc.date.issued | 2002 | |
Cita de ítem | dc.identifier.citation | NeuroReport, Volumen 13, Issue 4, 2018, Pages 491-496 | |
Identifier | dc.identifier.issn | 09594965 | |
Identifier | dc.identifier.other | 10.1097/00001756-200203250-00027 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/163609 | |
Abstract | dc.description.abstract | We have established two immortalized cell lines from dorsal root ganglia of normal (G4b) and trisomy 16 mice (GTI), a model for Down syndrome. By immunohistochemistry, both cell lines exhibit neuronal traits and lack glial markers. GTI cells exhibited greater [3H]choline uptake than G4b cells. K+ and nicotine-mediated acetylcholine release was greater in GTI cells. Basal intracellular Ca2+ concentration ([Ca2+]i) was significantly lower in GTI cells. More GTI cells responded to neurotransmitters with a transient [Ca2+]i increase compared to G4b cells, but both cell types showed similar amplitudes of [Ca2+]i responses. The results show that both cell lines retain neuronal characteristics and respond to specific neurotransmitter stimuli. Altered GTI cell responses could be related to neuronal pathophysiology in Down's syndrome. © 2002 Lippincott Williams & Wilkins. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Lippincott Williams and Wilkins | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | NeuroReport | |
Keywords | dc.subject | Calcium signaling | |
Keywords | dc.subject | Choline uptake | |
Keywords | dc.subject | Down syndrome | |
Keywords | dc.subject | Murine trisomy 16 | |
Título | dc.title | A dorsal root ganglia cell line derived from trisomy 16 fetal mice, a model for Down syndrome | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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