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Author | dc.contributor.author | Constandil, Luis | |
Author | dc.contributor.author | Pelissier Serrano, Teresa | |
Author | dc.contributor.author | Soto Moyano, Rubén | |
Author | dc.contributor.author | Mondaca, Mauricio | |
Author | dc.contributor.author | Sáez, Hernán | |
Author | dc.contributor.author | Laurido, Claudio | |
Author | dc.contributor.author | Muñoz, Carlos | |
Author | dc.contributor.author | López, Nandy | |
Author | dc.contributor.author | Hernández, Alejandro | |
Admission date | dc.date.accessioned | 2019-01-29T17:51:59Z | |
Available date | dc.date.available | 2019-01-29T17:51:59Z | |
Publication date | dc.date.issued | 2003 | |
Cita de ítem | dc.identifier.citation | Neuroscience Letters, Volumen 342, Issue 3, 2018, Pages 139-142 | |
Identifier | dc.identifier.issn | 03043940 | |
Identifier | dc.identifier.other | 10.1016/S0304-3940(03)00278-7 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/163636 | |
Abstract | dc.description.abstract | Cytokines produced by spinal cord glia after peripheral inflammation, infection or trauma have a relevant role in the maintenance of pain states. The effect of intrathecally administered interleukin-1β (IL-1β) on spinal cord nociceptive transmission was studied in normal and monoarthritic rats by assessing wind-up activity in a C-fiber-mediated reflex paradigm evoked by repetitive (1 Hz) electric stimulation. Low i.t. doses of IL-1β (0.03, 0.12, 0.5 and 2.0 ng) dose-dependently enhanced wind-up activity in normal rats, while higher doses (8.0 ng) only produced a marginal unsignificant effect. IL-1β administration to monoarthritic rats did not significantly change wind-up scores at any dose. Adaptive changes developed in the spinal cord during chronic pain may underlie the ineffectiveness of exogenous IL-1β to up-regulate nociceptive transmission. © 2003 Elsevier Science Ireland Ltd. All rights reserved. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Elsevier Ireland Ltd | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Neuroscience Letters | |
Keywords | dc.subject | C-fiber reflex | |
Keywords | dc.subject | Cytokine | |
Keywords | dc.subject | Interleukin-1β | |
Keywords | dc.subject | Monoarthritis | |
Keywords | dc.subject | Rat | |
Keywords | dc.subject | Spinal cord | |
Keywords | dc.subject | Wind-up | |
Título | dc.title | Interleukin-1β increases spinal cord wind-up activity in normal but not in monoarthritic rats | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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