Lung oxidative stress as related to exercise and altitude. Lipid peroxidation evidence in exhaled breath condensate: A possible predictor of acute mountain sickness
Author
dc.contributor.author
Araneda, O. F.
Author
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García, C.
Author
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Lagos, N.
Author
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Quiroga, G.
Author
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Cajigal, J.
Author
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Salazar, M. P.
Author
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Behn, C.
Admission date
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2019-01-29T17:57:02Z
Available date
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2019-01-29T17:57:02Z
Publication date
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2005
Cita de ítem
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European Journal of Applied Physiology, Volumen 95, Issue 5-6, 2018, Pages 383-390
Identifier
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14396319
Identifier
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10.1007/s00421-005-0047-y
Identifier
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https://repositorio.uchile.cl/handle/2250/163914
Abstract
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Lung oxidative stress (OS) was explored in resting and in exercising subjects exposed to moderate and high altitude. Exhaled breath condensate (EBC) was collected under field conditions in male high-competition mountain bikers performing a maximal cycloergometric exercise at 670 m and at 2,160 m, as well as, in male soldiers climbing up to 6,125 m in Northern Chile. Malondialdehyde concentration [MDA] was measured by high-performance liquid chromatography in EBC and in serum samples. Hydrogen peroxide concentration [H2O2] was analysed in EBC according to the spectrophotometric FOX2 assay. [MDA] in EBC of bikers did not change while exercising at 670 m, but increased from 30.0 ± 8.0 to 50.0 ± 11.0 nmol l-1 (P < 0.05) at 2,160 m. Concomitantly, [MDA] in serum and [H2O2] in EBC remained constant. On the other hand, in mountaineering soldiers, [H2O2] in EBC under resting conditions increased from 0.30 ± 0.12 μmol l-1 at 670 m to 1.14 ± 0.29 μmol l-1 immediately on return from the mountain.
Lung oxidative stress as related to exercise and altitude. Lipid peroxidation evidence in exhaled breath condensate: A possible predictor of acute mountain sickness