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Authordc.contributor.authorAraya, Julia 
Authordc.contributor.authorRodrigo Salinas, Ramón 
Authordc.contributor.authorVidela Cabrera, Luis
Authordc.contributor.authorThielemann, Lilian 
Authordc.contributor.authorOrellana, Myriam 
Authordc.contributor.authorPettinelli, Paulina 
Authordc.contributor.authorPoniachik Teller, Jaime 
Cita de ítemdc.identifier.citationClinical Science, Volumen 106, Issue 6, 2018, Pages 635-643
Abstractdc.description.abstractHepatic steatosis is a major feature associated with NAFLD (non-alcoholic fatty liver disease). The aims of the present study were to assess the levels of PUFA (polyunsaturated fatty acids) in liver total lipids, triacylglycerols (triglycerides) and phospholipids of NAFLD patients in relation to those in adipose tissue and hepatic indexes related to oxidative stress as factors contributing to hepatic steatosis. Eleven control subjects and 19 patients with NAFLD were studied. Analysis of liver and abdominal adipose tissue fatty acids was carried out by GLC. The liver content of protein carbonyl groups and malondialdehyde were taken as indexes related to oxidative stress. NAFLD patients had a depletion in LCPUFA (long-chain PUFA) of the n-6 and n-3 series in liver triacylglycerols, with decreased 20:4,n-6/18:2,n-6 and (20:5,n-3 + 22:6,n-3)/18:3,n-3 ratios, whereas liver phospholipids contained higher n-6 and lower n-3 LCPUFA. These findings were accompanied by an enhancement of (i) n-6/n
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceClinical Science
Keywordsdc.subjectLipid peroxidation
Keywordsdc.subjectLong-chain polyunsaturated fatty acid
Keywordsdc.subjectOxidative stress
Keywordsdc.subjectProtein carbonylation
Keywordsdc.subjectTrans fatty acid
Títulodc.titleIncrease in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile