Post-coital administration of levonorgestrel does not interfere with post-fertilization events in the new-world monkey Cebus apella
Author
dc.contributor.author
Ortiz, M. E.
Author
dc.contributor.author
Ortiz, R. E.
Author
dc.contributor.author
Fuentes, M. A.
Author
dc.contributor.author
Parraguez Gamboa, Víctor
Author
dc.contributor.author
Croxatto, Horacio B.
Admission date
dc.date.accessioned
2019-01-29T17:57:08Z
Available date
dc.date.available
2019-01-29T17:57:08Z
Publication date
dc.date.issued
2004
Cita de ítem
dc.identifier.citation
Human Reproduction, Volumen 19, Issue 6, 2018, Pages 1352-1356
Identifier
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02681161
Identifier
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10.1093/humrep/deh180
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163934
Abstract
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Background: Experimental evidence to disprove the belief that emergency contraception with levonorgestrel (LNG) prevents pregnancy by interfering with post-fertilization events is lacking. Here we determined the effect of post-coital and pre-ovulatory administration of LNG on fertility and ovulation, respectively, in the Cebus monkey. Methods: To determine the effect on fertility, LNG 0.75 mg or vehicle were administered orally or s.c. once or twice within the first 24 h after mating occurring very close to the time of ovulation. Females that became pregnant were aborted with mifepristone and re-entered the study after a resting cycle until each of 12 females had contributed, in a randomized order, two LNG and two vehicle-treated cycles. To determine the effect on ovulation, LNG 0.75 mg or vehicle were injected twice coinciding with follicles smaller or larger than 5 mm in diameter. Six females contributed five treated cycles each. Results: The pregnancy rate was identical in vehicle-