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Author | dc.contributor.author | Osorio Olivares, Mauricio | |
Author | dc.contributor.author | Rezende, Marcos Caroli | |
Author | dc.contributor.author | Sepúlveda Boza, Silvia | |
Author | dc.contributor.author | Cassels Niven, Bruce | |
Author | dc.contributor.author | Fierro, Angélica | |
Admission date | dc.date.accessioned | 2019-01-29T17:57:08Z | |
Available date | dc.date.available | 2019-01-29T17:57:08Z | |
Publication date | dc.date.issued | 2004 | |
Cita de ítem | dc.identifier.citation | Bioorganic and Medicinal Chemistry, Volumen 12, Issue 15, 2018, Pages 4055-4066 | |
Identifier | dc.identifier.issn | 09680896 | |
Identifier | dc.identifier.other | 10.1016/j.bmc.2004.05.033 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/163937 | |
Abstract | dc.description.abstract | Twenty-nine arylisopropylamines, substituted at the β-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-B inhibiting activity, which was absent in the hydroxy, methoxy, and β-unsubstituted analogues. These results suggest that selective affinity for the two MAO isoforms in this family of compounds is modulated not only by the aryl substitution pattern but also by the side-chain substituents on the arylalkylamine scaffold. © 2004 Elsevier Ltd. All rights reserved. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Bioorganic and Medicinal Chemistry | |
Keywords | dc.subject | β-Methoxyphenylisopropylamines | |
Keywords | dc.subject | β-Substituted phenylisopropylamines | |
Keywords | dc.subject | Cathinones | |
Keywords | dc.subject | Monoamine oxidase inhibition | |
Keywords | dc.subject | Norephedrines | |
Título | dc.title | MAO inhibition by arylisopropylamines: The effect of oxygen substituents at the β-position | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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