Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren's syndrome: Association with mononuclear cell infiltration
Author
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Molina, C.
Author
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Alliende, C.
Author
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Aguilera, S.
Author
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Kwon, Y. J.
Author
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Leyton, L.
Author
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Martínez, B.
Author
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Leyton, C.
Author
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Pérez, P.
Author
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González Burgos, María Julieta
Admission date
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2019-01-29T17:57:11Z
Available date
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2019-01-29T17:57:11Z
Publication date
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2006
Cita de ítem
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Annals of the Rheumatic Diseases, Volumen 65, Issue 2, 2018, Pages 178-183
Identifier
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00034967
Identifier
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10.1136/ard.2004.033837
Identifier
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https://repositorio.uchile.cl/handle/2250/163948
Abstract
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Objective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjögren's syndrome, and to relate this organisation to inflammatory cell invasion of acini and ducts. Methods: Immunohistochemistry for laminin and type IV collagen was undertaken on sections of labial salivary glands from 30 patients with Sjögren's syndrome, 10 control subjects, and 24 controls with chronic sialoadenitis. Immunohistochemistry reaction alterations to cell morphology, and the presence of inflammatory cells in acini and ducts were evaluated and scored using a semiquantitative method. Results: Changes in the expression of laminin and type IV collagen in the basal lamina of acini and ducts of labial salivary glands from patients with Sjögren's syndrome were more pronounced than in labial salivary glands from control groups. A remarkable characteristic was the disorganisation of the basal lam
Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren's syndrome: Association with mononuclear cell infiltration