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Author | dc.contributor.author | Cerecetto, Hugo | |
Author | dc.contributor.author | González, M. | |
Author | dc.contributor.author | Lavaggi, M. L. | |
Author | dc.contributor.author | Aravena, M. A. | |
Author | dc.contributor.author | Rigol, C. | |
Author | dc.contributor.author | Olea Azar, Claudio | |
Author | dc.contributor.author | Azqueta, A. | |
Author | dc.contributor.author | López de Ceráin, Adela | |
Author | dc.contributor.author | Monge, A. | |
Author | dc.contributor.author | Bruno, A. M. | |
Admission date | dc.date.accessioned | 2019-03-11T12:51:23Z | |
Available date | dc.date.available | 2019-03-11T12:51:23Z | |
Publication date | dc.date.issued | 2006 | |
Cita de ítem | dc.identifier.citation | Medicinal Chemistry, Volumen 2, Issue 5, 2018, Pages 511-521 | |
Identifier | dc.identifier.issn | 15734064 | |
Identifier | dc.identifier.other | 10.2174/157340606778250207 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/164197 | |
Abstract | dc.description.abstract | The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2-hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed. © 2006 Bentham Science Publishers Ltd. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Medicinal Chemistry | |
Keywords | dc.subject | Bioreductive compounds | |
Keywords | dc.subject | Cyclic voltammetry | |
Keywords | dc.subject | DNA | |
Keywords | dc.subject | Phenazine 5,10-dioxide derivatives | |
Título | dc.title | Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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