Show simple item record

Authordc.contributor.authorRodríguez, Pablo 
Authordc.contributor.authorRosselot, Gastón 
Cita de ítemdc.identifier.citationFASEB Journal, Volumen 10, Issue 3, 2018,
Abstractdc.description.abstractZinc (Zn) supplementation has been shown to stimulate longitudinal growth under marginal nutritional status. The mechanisms by which Zn stimulates longitudinal growth are still unknown. We have previously investigated the effects of Zn on proliferation and proteoglycan (PG) synthesis on epiphyseal chondrocytes. In this study we report the effects of Zn on structural characteristics of the PG synthesized by cultured chondrocytes. Chicken chondrocytes were cultured in a serum-free medium, supplemented ZnCl2 {0-1 nM). PG were labeled with '5SO4, and characterized by ion-exchange and molecular sieve chromatography, and by their sensitivity to enzymatic treatment. PG synthesized by hypertrophie chondrocytes in the presence or absence of Zn exhibited similar structural characteristics. In contrast. PG synthesized by proliferating chondrocytes in the presence of Zn show higher mean charge density, and lower hydrodynamic size that those synthesized in the absence of Zn. The composition and hyd
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFASEB Journal
Keywordsdc.subjectAgricultural and Biological Sciences (miscellaneous)
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectCell Biology
Títulodc.titleEffects of zinc on structural characteristics of proteoglycans synthesized by proliferating and hypertrophic chondrocytes in culture
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile