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Authordc.contributor.authorAvellaira, C. 
Authordc.contributor.authorVillavicencio, A. 
Authordc.contributor.authorBacallao, Ketty 
Authordc.contributor.authorGabler Neale, Fernando 
Authordc.contributor.authorWells, P. 
Authordc.contributor.authorRomero Osses, Carmen 
Authordc.contributor.authorVega Blanco, María Margarita 
Cita de ítemdc.identifier.citationHuman Reproduction, Volumen 21, Issue 12, 2018, Pages 3116-3121
Abstractdc.description.abstractBackground: The hormonal alterations observed in women with polycystic ovary syndrome (PCOS) may promote implantation failure as well as disruption of their endometrial homeostasis. To evaluate cell survival of mid-secretory endometrium from untreated women with PCOS, we measured the expression of apoptosis and proliferation-related proteins. Methods: A case-control study of 11 patients with PCOS and 11 fertile women in the Hospital Research Unit was performed. Endometrial samples were obtained from PCOS women (PCOSE) and fertile healthy women (CE) during the mid-secretory phase of the menstrual cycle. Protein expressions for Akt, p-AktSer473 and p-AktThr308, Bad, p-BadSer136, Bcl-2, Bax and pro-caspase-3/caspase-3, were assessed by western blot, and Ki67 and p-histone-3 (p-H3) by immunohistochemistry. Results: In CE and PCOSE, a predominance of p-AktThr308 over p-AktSer473 is observed; p-BadSer136 expression is higher in PCOSE than in CE (P < 0.05). Also, Bcl-2 protein is overexpresse
Publisherdc.publisherOxford University Press
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceHuman Reproduction
Keywordsdc.subjectAkt signalling pathways
Keywordsdc.subjectApoptosis-related proteins
Keywordsdc.subjectCell survival
Keywordsdc.subjectPolycystic ovary syndrome
Títulodc.titleExpression of molecules associated with tissue homeostasis in secretory endometria from untreated women with polycystic ovary syndrome
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile