Role of Azathioprine in steroid resistant non infectious ocular inflammatory diseases Eficacia de la azatioprina en la enfermedad ocular inflamatoria no infecciosa resistente a tratamiento esteroidal sistémico
Author
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Cuchacovich, Miguel
Author
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Pacheco, Patricio
Author
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Estay Díaz, Gonzalo
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Rojas, Basilio
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Stoppel, Juan
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Merino, Guillermo
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Verdaguer, Juan Ignacio
Author
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Verdaguer, Juan
Author
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Villarroel, Francisco
Admission date
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2019-03-11T12:54:15Z
Available date
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2019-03-11T12:54:15Z
Publication date
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2007
Cita de ítem
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Revista Medica de Chile, Volumen 135, Issue 6, 2018, Pages 702-707
Identifier
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00349887
Identifier
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07176163
Identifier
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https://repositorio.uchile.cl/handle/2250/164373
Abstract
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Background: Topical and systemic steroids are the first line of treatment of non infectious inflammatory ocular disease. Immunosuppresants are reserved as a second line treatment. Aim: To evaluate the role of Azathioprine (AZA) as a coadyuvant immunosuppressive treatment for non infectious ocular inflammatory diseases (OIDs) resistant to systemic steroid therapy in a retrospective, noncomparative interventional case series. Patients and methods: Patients using oral Prednisone due to an active or recurrent OID, without clinical response, and not receiving any other immunosuppressive treatment were studied. A standard protocol of oral Prednisone (0.5 mg/kg/day) and oral AZA (2-3 mg/kg/day) during one year was used. Ocular and systemic monthly evaluations were done including relapse rate, steroid dosage, inflammatory score and visual acuity. Results: Thirty patients (10 male) aged 18-75 years (mean 44 years) were studied. Three had bilateral anterior uveitis, one had pars planitis, four h
Role of Azathioprine in steroid resistant non infectious ocular inflammatory diseases Eficacia de la azatioprina en la enfermedad ocular inflamatoria no infecciosa resistente a tratamiento esteroidal sistémico