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Author | dc.contributor.author | Arriagada, Osvaldo | |
Author | dc.contributor.author | Constandil, Luis | |
Author | dc.contributor.author | Hernández, Alejandro | |
Author | dc.contributor.author | Barra, Rafael | |
Author | dc.contributor.author | Soto Moyano, Rubén | |
Author | dc.contributor.author | Laurido, Claudio | |
Admission date | dc.date.accessioned | 2019-03-11T12:54:20Z | |
Available date | dc.date.available | 2019-03-11T12:54:20Z | |
Publication date | dc.date.issued | 2007 | |
Cita de ítem | dc.identifier.citation | International Journal of Neuroscience, Volumen 117, Issue 5, 2018, Pages 617-625 | |
Identifier | dc.identifier.issn | 00207454 | |
Identifier | dc.identifier.issn | 15635279 | |
Identifier | dc.identifier.other | 10.1080/00207450600773806 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/164396 | |
Abstract | dc.description.abstract | To investigate the contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered interleukin-1β (IL-1β) was studied in rats treated with the glial cell inactivator propentofylline and submitted to a C-fiber-mediated reflex paradigm evoked by single and repetitive (wind-up) electric stimulation. Intrathecal IL-1β did not modify the C reflex integrated activity in either group of animals, while producing increased wind-up in intact and decreased wind-up in propentofylline pre-treated rats. Results suggest that the excitatory effect of IL-1β on spinal wind-up activity in healthy rats is produced by a glial mediator, whereas the inhibitory effect resulted from a direct effect of the cytokine on dorsal horn neurons. Copyright © 2007 Informa Healthcare. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | International Journal of Neuroscience | |
Keywords | dc.subject | C-fiber reflex | |
Keywords | dc.subject | Glia | |
Keywords | dc.subject | Interleukin-1β | |
Keywords | dc.subject | Pain | |
Keywords | dc.subject | Propentofylline | |
Keywords | dc.subject | Spinal cord | |
Keywords | dc.subject | Wind-up | |
Título | dc.title | Effects of interleukin-1β on spinal cord nociceptive transmission in intact and propentofylline-treated rats | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile