How reliable and robust are current biomarkers for copper status?
Author
dc.contributor.author
Danzeisen, Ruth
Author
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Araya, Magdalena
Author
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Harrison, Brenda
Author
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Keen, Carl
Author
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Solioz, Marc
Author
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Thiele, Dennis
Author
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Mcardle, Harry J.
Admission date
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2019-03-11T12:54:20Z
Available date
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2019-03-11T12:54:20Z
Publication date
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2007
Cita de ítem
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British Journal of Nutrition, Volumen 98, Issue 4, 2018, Pages 676-683
Identifier
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00071145
Identifier
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14752662
Identifier
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10.1017/S0007114507798951
Identifier
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https://repositorio.uchile.cl/handle/2250/164397
Abstract
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Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects. Malnourished children, the elderly, and pregnant or lactating females may be susceptible for Cu deficiency. Cu status and exposure in the population can currently not be easily measured, as neither plasma Cu nor plasma cuproenzymes reflect Cu status precisely. Some blood markers (such as ceruloplasmin) indicate severe Cu depletion, but do not inversely respond to Cu excess, and are not suitable to indicate marginal states. A biomarker of Cu is needed that is sensitive to small changes in Cu status, and that responds to Cu excess as well as deficiency. Such a marker will aid in monitoring Cu status in large populations, and will help to avoid chronic health effects (for example, liver damage in chronic toxicity, osteoporosis, loss of collagen stability, or increased susceptibility to infections in deficiency). The advent