Show simple item record

Authordc.contributor.authorHetz Flores, Claudio
Admission datedc.date.accessioned2019-03-11T12:54:56Z
Available datedc.date.available2019-03-11T12:54:56Z
Publication datedc.date.issued2007
Cita de ítemdc.identifier.citationAntioxidants and Redox Signaling, Volumen 9, Issue 12, 2018, Pages 2345-2355
Identifierdc.identifier.issn15230864
Identifierdc.identifier.other10.1089/ars.2007.1793
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/164414
Abstractdc.description.abstractProgrammed cell death is essential for the development and maintenance of cellular homeostasis, and its deregulation results in a variety of pathologic conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death that operate at the mitochondrial membrane to control caspase activation. This family is comprised both of antiapoptotic and proapoptotic members, in which a subset of proapoptotic members, called BH3-only proteins, acts as upstream activators of the core proapoptotic pathway. In addition to their known role at the mitochondria, different BCL-2-related proteins are located to the endoplasmic reticulum (ER) membrane, where new functions have been recently proposed. In this review, evidence is presented indicating that members of the BCL-2 protein family are contained in multiprotein complexes at the ER, regulating diverse cellular processes including autophagy, calcium homeostasis, the unfolded-protein response, ER membrane remodeling
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAntioxidants and Redox Signaling
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectPhysiology
Keywordsdc.subjectMolecular Biology
Keywordsdc.subjectClinical Biochemistry
Keywordsdc.subjectCell Biology
Títulodc.titleER stress signaling and the BCL-2 family of proteins: From adaptation to irreversible cellular damage
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile