Biphasic insulin aspart for the management of diabetic patients with unsatisfactory metabolic control Tratamiento con insulina aspártica bifásica en pacientes con diabetes en mal control metabólico. Experiencia clínica programada
Author
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García de los Ríos, Manuel
Author
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Wolff Fernández, Carlos
Author
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Duarte, Erika
Admission date
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2019-03-11T12:55:03Z
Available date
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2019-03-11T12:55:03Z
Publication date
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2007
Cita de ítem
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Revista Medica de Chile, Volumen 135, Issue 10, 2018, Pages 1253-1260
Identifier
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00349887
Identifier
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07176163
Identifier
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https://repositorio.uchile.cl/handle/2250/164446
Abstract
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Background: Biophasic insulin aspart (InAsBi) is a mixture of 30% of rapid acting soluble aspart insulin and 70% aspart insulin retarded with protamine. The soluble portion reduces postprandial serum glucose rises and the retarded portion reduces basal glucose levels. Aim: To assess the efficacy of biphasic insulin aspart in diabetics with a bad metabolic control. Material and methods: Multicentric study that included diabetic patients with a glycosilated hemoglobin over 7% that were transferred to treatment with InAsBi, given in one to three daily doses, according to glycemic control and followed for 12 weeks. At the end of follow up, glycosilated hemoglobin levels (HbA1c) were measured again. Results: One hundred ninety six patients were enrolled and 154, age 59±12 (84 females), completed the follow up. HbA1c levels decreased in at least 1% in 96 and increased in eight cases. In the total group HbA1c decreased from 10.1 ±1.7 to 8.4 ±1.4% (p <0.01). Those with higher initial values an
Biphasic insulin aspart for the management of diabetic patients with unsatisfactory metabolic control Tratamiento con insulina aspártica bifásica en pacientes con diabetes en mal control metabólico. Experiencia clínica programada