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Authordc.contributor.authorPelissier Serrano, Teresa 
Authordc.contributor.authorInfante, Claudio 
Authordc.contributor.authorConstandil, Luis 
Authordc.contributor.authorEspinosa, Jeannette 
Authordc.contributor.authorLapeyra, Carolina De 
Authordc.contributor.authorHernández, Alejandro 
Admission datedc.date.accessioned2019-03-11T12:55:04Z
Available datedc.date.available2019-03-11T12:55:04Z
Publication datedc.date.issued2008
Cita de ítemdc.identifier.citationPain, Volumen 134, Issue 1-2, 2018, Pages 113-127
Identifierdc.identifier.issn03043959
Identifierdc.identifier.other10.1016/j.pain.2007.04.011
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/164449
Abstractdc.description.abstractWe assessed whether intrathecal administration of the uncompetitive and competitive NMDA receptor antagonists ketamine and (±)CPP, respectively, could produce differential modulation on chemical and mechanical nociception in normal and monoarthritic rats. In addition, the antinociceptive interaction of ketamine and (±)CPP on monoarthritic pain was also studied using isobolographic analysis. Monoarthritis was produced by intra-articular injection of complete Freund's adjuvant into the tibio-tarsal joint. Four weeks later, the antinociceptive effect of intrathecal administration of the drugs alone or combined was evaluated by using the intraplantar capsaicin and the paw pressure tests. Ketamine (0.1, 1, 10, 30, 100, 300 and 1000 μg i.t.) and (±)CPP (0.125, 2.5, 7.5, 12.5, 25 and 50 μg i.t.) produced significantly greater dose-dependent antinociception in the capsaicin than in the paw pressure test. Irrespective of the nociceptive test employed, both antagonists showed greater antinocicep
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePain
Keywordsdc.subject(±)CPP
Keywordsdc.subjectCapsaicin
Keywordsdc.subjectKetamine
Keywordsdc.subjectMonoarthritic rat
Keywordsdc.subjectNMDA receptor
Keywordsdc.subjectPaw pressure
Títulodc.titleAntinociceptive effect and interaction of uncompetitive and competitive NMDA receptor antagonists upon capsaicin and paw pressure testing in normal and monoarthritic rats
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile