DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function
Author
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Mendoza-Topaz, Carolina
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Urra, Francisco
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Barría, Romina
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Albornoz, Valeria
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Ugalde, Diego
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Thomas, Ulrich
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Gundelfinger, Eckart D.
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Delgado, Ricardo
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Kukuljan Padilla, Manuel
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Sanxaridis, Parthena D.
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Tsunoda, Susan
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Ceriani, M. Fernanda
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Budnik, Vivian
Author
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Sierralta, Jimena
Admission date
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2019-03-11T12:55:05Z
Available date
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2019-03-11T12:55:05Z
Publication date
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2008
Cita de ítem
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Journal of Neuroscience, Volumen 28, Issue 1, 2018, Pages 304-314
Identifier
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02706474
Identifier
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02706474
Identifier
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10.1523/JNEUROSCI.4395-07.2008
Identifier
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https://repositorio.uchile.cl/handle/2250/164458
Abstract
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The synaptic membrane-associated guanylate kinase (MAGUK) scaffolding protein family is thought to play key roles in synapse assembly and synaptic plasticity. Evidence supporting these roles in vivo is scarce, as a consequence of gene redundancy in mammals. The genome of Drosophila contains only one MAGUK gene, discs large (dlg), from which two major proteins originate: DLGA [PSD95 (postsynaptic density 95)-like] and DLGS97 [SAP97 (synapse-associated protein)-like]. These differ only by the inclusion in DLGS97 of an L27 domain, important for the formation of supramolecular assemblies. Known dlg mutations affect both forms and are lethal at larval stages attributable to tumoral overgrowth of epithelia. We generated independent null mutations for each, dlgA and dlgS97. These allowed unveiling of a shift in expression during the development of the nervous system: predominant expression of DLGA in the embryo, balanced expression of both during larval stages, and almost exclusive DLGS97 exp