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Authordc.contributor.authorLagos, Rosanna 
Authordc.contributor.authorFasano, Alessio 
Authordc.contributor.authorWasserman, Steven S. 
Authordc.contributor.authorPrado Jiménez, Valeria 
Authordc.contributor.authorSan Martin, Oriana 
Authordc.contributor.authorAbrego, Paulina 
Authordc.contributor.authorLosonsky, Genevieve A. 
Authordc.contributor.authorAlegria, Silvia 
Authordc.contributor.authorLevine, Myron M. 
Cita de ítemdc.identifier.citationJournal of Infectious Diseases, Volumen 180, Issue 5, 2018, Pages 1709-1712
Abstractdc.description.abstractSeveral live oral vaccines (polio, bovine rotavirus, CVD 103-HgR cholera) are less immunogenic in developing than in industrialized countries. It was hypothesized that proximal small bowel bacterial overgrowth (common in children in less developed countries but rare in industrialized settings) diminishes the vibriocidal antibody response to CVD 103-HgR. In total, 202 fasting Santiago schoolchildren aged 5-9 years had lactulose breath H2 tests to detect proximal small bowel bacteria 1 day before ingesting CVD 103-HgR. Florid small bowel overgrowth was observed in 10 (5.6%) of 178 analyzable children. In children with florid overgrowth, vibriocidal seroconversion differed little from other children (60% vs. 67%), but the geometric mean titer was lower (160 vs. 368; P = .25). By logistic regression, increased peak breath H2 at small bowel time points was associated with diminished seroconversion (P = .04), as was the interaction of H2 value and weight (children >25 kg had lower seroconver
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Infectious Diseases
Keywordsdc.subjectImmunology and Allergy
Keywordsdc.subjectMedicine (all)
Keywordsdc.subjectInfectious Diseases
Títulodc.titleEffect of small bowel bacterial overgrowth on the immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile