Effect of a single doses intraperitoneal of cypermethrin in brain somatosensory area of mice CF-1 Efecto de dosis única intraperitoneal de cipermetrina en la corteza cerebral somatosensorial de ratones CF- 1

Abstract

The cypermethrin is a pesticide widely used in agriculture and public health. Their histopathological effects at central nervous system level, little have been studied, even though has demonstrated cases of poisoning in humans with important neurological commitment. The aim of this work is to know the effects a intraperitoneal single dose of cypermethrin on neuronal morphology of somatosensory cortex (superficial and deep laminae) of mice CF-1. 35 mice were separated in three groups: control (n=5), control vehicle (n=15) and experimental (n=15); the two last sacrificed groups 1, 8, 18, 26 and 35 days, three animals per group. The brain were removed, fixed, and process with routine technique, for a morphometric analysis. Statistical analysis with Kruskal Wallís test. We demonstrated corresponding morphologic alterations until death neuronal, in all studied laminae, at the different time intervals.