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Authordc.contributor.authorVarela, Nelson M. 
Authordc.contributor.authorQuiñones, Luis A. 
Authordc.contributor.authorOrellana, Myriam 
Authordc.contributor.authorPoniachik Teller, Jaime 
Authordc.contributor.authorCsendes Juhasz, Attila
Authordc.contributor.authorSmok Sahid, Gladys 
Authordc.contributor.authorRodrigo Salinas, Ramón 
Authordc.contributor.authorCáceres, Dante D. 
Authordc.contributor.authorVidela Cabrera, Luis 
Admission datedc.date.accessioned2019-03-11T12:56:06Z
Available datedc.date.available2019-03-11T12:56:06Z
Publication datedc.date.issued2008
Cita de ítemdc.identifier.citationBiological Research, Volumen 41, Issue 1, 2018, Pages 81-92
Identifierdc.identifier.issn07169760
Identifierdc.identifier.issn07176287
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/164603
Abstractdc.description.abstractCYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene. The aim of this study was to investigate hepatic levels, activity, and polymorphisms of the CYP2E1 gene to correlate it with clinical and histological features in 48 female obese NASH patients. Subjects were divided into three groups: (i) normal; (ii) steatosis; and (iii) steatohepatitis. CYP2E1 protein level was assayed in microsomes from liver biopsies, and in vivo chlorzoxazone hydroxylation was determined by HPLC. Genomic DNA was isolated for genotype analysis through PCR. The results showed that liver CYP2E1 content was significantly higher in the steatohepatitis (45%; p=0.024) and steatosis (22%; p=0.032) group compared with normal group. Chlorzoxazone hydroxylase activity showed significant enhancement in the steatohepatitis group (15%, p=0.027) compared with the normal group. c2 rare allele of Rsa1/Pst1
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiological Research
Keywordsdc.subjectChlorozoxazone
Keywordsdc.subjectCYP2E1
Keywordsdc.subjectGenotype
Keywordsdc.subjectNASH
Keywordsdc.subjectObesity
Keywordsdc.subjectSteatohepatitis
Títulodc.titleStudy of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, noalcoholic steatohepatitis obese women
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile