Immunohistochemistry for pituitary hormones and Ki-67 in growth hormone producing pituitary adenomas Evaluación por inmunohistoquímica de la expresión de hormonas hipofisiarias y del marcador de proliferación celular Ki-67 en tejido de adenomas causantes
Author
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Brito, Julio
Author
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Sáez, Lya
Author
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Lemp, Melchor
Author
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Liberman, Claudio
Author
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Michelsen, Harold
Author
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Araya Q., A. Verónica
Admission date
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2019-03-11T12:56:06Z
Available date
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2019-03-11T12:56:06Z
Publication date
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2008
Cita de ítem
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Revista Medica de Chile, Volumen 136, Issue 7, 2018, Pages 831-836
Identifier
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00349887
Identifier
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07176163
Identifier
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https://repositorio.uchile.cl/handle/2250/164606
Abstract
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Background: Growth hormone (GH) producing adenomas, frequently express several hormones. This condition could confer them a higher proliferative capacity. Ki-67 is a nuclear protein antigen that is a marker for proliferative activity. Aim: To measure the immunohistochemical hormone expression in pituitary adenomas, excised from patients with acromegaly. To determine if the plurihormonal condition of these adenomas is associated with a higher proliferative capacity, assessed through the expression of Ki-67. Material and methods: Forty one paraffin embedded surgical samples of pituitary adenomas from patients with acromegalia were studied. Immunohistochemistry for GH, prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), adrenocorticotropin (ACTH) and for the expression of Ki-67 was carried out. Results: All samples were positive for GH. Twenty seven had positive staining for PRL, 12 had positive staining for glycoproteic hormon
Immunohistochemistry for pituitary hormones and Ki-67 in growth hormone producing pituitary adenomas Evaluación por inmunohistoquímica de la expresión de hormonas hipofisiarias y del marcador de proliferación celular Ki-67 en tejido de adenomas causantes